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  • Avapritinib 100mg

Avapritinib 100mg

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Avapritinib is used for gastrointestinal stromal tumour that cannot be removed by surgery or has spread and has a PDGFRA exon 18 mutation, including the D842V mutation.

It is also used for advanced systemic mastocytosis, a rare disease where abnormal mast cells build up in the body.

Usual adult dose range: 25mg to 300mg once daily; lower doses are used for some mast cell diseases and higher doses for selected gastrointestinal stromal tumours.

Indications vary by country and change over time; this website contains information for general patient information and should be checked against local prescribing information before clinical use.

Verification Approach: Each indication and usual dose-range sentence was drafted from at least two recognised medicines information sources, usually FDA/DailyMed or an FDA label plus EMA/eMC, MedlinePlus, Mayo Clinic, Cancer Research UK, NCI/ Cancer.gov, or another reputable medicines-information source. Doses are general adult/patient-information ranges and must not be used to prescribe or change treatment.
  • FDA/DailyMed prescribing information and FDA Oncology/Hematology approval notifications.
  • EMA and UK eMC Summary of Product
    Characteristics and patient leaflets where available.
  • NCI Cancer Drug Information/Cancer.gov and Cancer Research UK medicine information where available.
  • MedlinePlus, NHS/NICE, and other national medicines information for non-oncology or immune/respiratory medicines.
  • Peer-reviewed FDA approval summaries or manufacturer regulatory notices for very new, withdrawn, or region-specific
    indications.