• Cobimetinib 20mg

Cobimetinib 20mg

SKU:52231

Cobimetinib is used with vemurafenib for melanoma that cannot be removed by surgery or has spread and has a BRAF V600 mutation.

It is also used for adults with histiocytic neoplasms, a rare group of blood-related disorders that includes Erdheim-Chester disease, Rosai-Dorfman disease, and Langerhans cell histiocytosis.

Usual adult dose range: 20mg to 60mg once daily on days 1 to 21 of each 28-day cycle; the usual starting dose is 60mg once daily with vemurafenib.


Indications vary by country and change over time; this website contains information for general patient information and should be checked against local prescribing information before clinical use.

Verification Approach: Each indication and usual dose-range sentence was drafted from at least two recognised medicines information sources, usually FDA/DailyMed or an FDA label plus EMA/eMC, MedlinePlus, Mayo Clinic, Cancer Research UK, NCI/ Cancer.gov, or another reputable medicines-information source. Doses are general adult/patient-information ranges and must not be used to prescribe or change treatment.


  • FDA/DailyMed prescribing information and FDA Oncology/Hematology approval notifications.
  • EMA and UK eMC Summary of Product
    Characteristics and patient leaflets where available.
  • NCI Cancer Drug Information/Cancer.gov and Cancer Research UK medicine information where available.
  • MedlinePlus, NHS/NICE, and other national medicines information for non-oncology or immune/respiratory medicines.
  • Peer-reviewed FDA approval summaries or manufacturer regulatory notices for very new, withdrawn, or region-specific
    indications.